Researchers have had success growing organs
in controlled lab environments, but repeating that feat inside a
complex, messy animal body? That's more than a little tricky. However,
researchers at the University of Edinburgh have managed that daunting
feat for the first time. They've grown thymus glands
inside lab mice by "reprogramming" the genes in tissue-regenerating
cells and partnering those with support cells.
The team didn't have to
use scaffolds or other "cheats" to trigger the growth; it just injected
the cells and waited. There weren't even any obvious limitations. The
organs were full size (unlike the baby-like results from some experiments), and they were just as efficient at producing virus-fighting T-cells as the real deal.
The
catch, as you might have guessed, is the scale. Mice aren't nearly as
challenging to work on as humans, and the thymus is one of the simplest
organs in any animal. It wouldn't be nearly as easy to give you a new
heart or lung. If the University keeps making progress, though, it
could shake up the transplant process. Patients wouldn't have to wait
for donors whose tissues are good matches, and people who've lost much
of their immune system (such as bone marrow transplant recipients) could
rebuild faster. You won't get on-demand organs any time soon, but the
concept isn't as far-fetched as it once was.
Monday, August 25, 2014
Scientists grow whole organs inside animals for the first time
8:59 AM
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